Endocrine Abstracts

Introduction: Inflammatory markers play an important role in the development of type 2 diabetes and coronary artery disease. Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C chemokine family and a potent chemotactic factor for monocytes.The aim of our study was to investigate the effect of MCP-1 A-2518G polymorphisms on the development of diabetic coronary heart disease.Subjects and methods: 53 diabetic patients wi...

Introduction: Inflammatory mechanisms play an important role in the development of cardiovascular diseases and diabetes. Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. Some studies have shown that CCR2 G190A polymorphism might be important for protection of susceptibility to some immunologically-mediated disorders. The aim of our study was to investigate the effec...